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KMID : 1201420130060020111
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Journal of Neurocritical Care
2013 Volume.6 No. 2 p.111 ~ p.114
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A Case of Cerebral Aspergillosis Diagnosed by Magnetic Resonance Imaging and Antigen Test
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Kim Sae-Ro-Mi
Kang Yeo-Jeong
Kim Tae-Eun
Sung Ki-Bum
Lee A-Leum
Chang Kee-Hyun
Park Sun-Ah
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Abstract
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Background:Aspergillosis involving central nervous system (CNS) is very rare. Recently we experienced an old woman with cerebral aspergillosis, in whom characteristic magnetic resonance imaging (MRI) findings and antigen test were helpful in diagnosis.
Case Report:A 87-year-old woman was admitted to the hospital due to diminished cognition and abnormal behavior for two weeks. On brain MRI small multiple conglomerated granulomatous lesions with surrounding extensive vasogenic edema, and multifocal small hemorrhages were observed in right temporal area. Additionally, the titer of Aspergillus antigen test was highly increased. With intravenous antifungal agents the patient’s clinical symptoms were markedly improved.
Conclusion:For CNS aspergillosis the urgent diagnosis followed by appropriate treatment is essential due to its high mortality. The characteristic brain MRI accompanied by high levels of aspergillosis antigen titer could be helpful diagnostic tool of CNS aspergillosis in special situations not being able to obtain pathologic confirmation.
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KEYWORD
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CNS infection , Aspergillosis , Voriconazole
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